CORRECT ANSWER:
Rely on the appraiser’s report and cancel the inspection.
Go ahead with the inspection.
Cancel the inspection and ask Uncle Charlie to take a look at the home for them.

Ryan and Jessica should definitely pay for a licensed home inspector. While an appraiser assesses the home's value, a home inspector dives deep into the home's structure and systems. If issues arise, this gives Ryan and Jessica a chance to either have the sellers fix them or renegotiate the contract.
As for Uncle Charlie, he might be a charming expert in his own mind, but his tip to save a few bucks now could end up costing Ryan and Jessica thousands down the line.